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Title: Antitumor Efficacy of Ceranib-2 with Nano-Formulation of PEG and Rosin Esters
Authors: Ben Taleb, Ali
Karakuş, Selcan
Tan, Ezgi
Ilgar, Merve
Kutlu, Özlem
Gözüaçık, Devrim
Kilislioğlu, Ayben
Keywords: Ceranib-2
Rosin ester
Issue Date: 2021
Publisher: Humana Press Inc
Abstract: Ceranib-2 is a recently discovered, poorly water-soluble potent ceramidase inhibitor, with the ability to suppress cancer cell proliferation and delay tumor growth. However, its poor water solubility and weak cellular bioavailability hinder its use as a therapeutic agent for cancer. PEGylated rosin esters are an excellent platform as a natural polymer for drug delivery applications, especially for controlling drug release due to their degradability, biocompatibility, capability to improve solubility, and pharmacokinetics of potent drugs. In this study, stable aqueous amphiphilic submicron-sized PEG400-rosin ester-ceranib-2 (PREC-2) particles, ranging between 100 and 350 nm in a 1:1 mixture, were successfully synthesized by solvent evaporation mediated by sonication. Conclusion: Stable aqueous PEGylated rosin ester nanocarriers might present a significant solution to improve solubility, pharmacokinetic, and bioavailability of ceranib-2, and hold promises for use as an anticancer adjacent drug after further investigations.
ISBN: 978-1-0716-0920-0; 978-1-0716-0919-4
ISSN: 1064-3745
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu

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