Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.13087/3176
Title: Highly Stable and Reproducible Biosensor Interface based on Chitosan and 2,5-Di(thienyl)pyrrole based Conjugated Polymer
Authors: Özkan, Betül Çicek
Soğancı Aras, Tuğba
Turhan, Hüseyin
Ak, Metin
Keywords: Glucose biosensor
Chitosan
Conducting polymer
rGO
Reduced Graphene Oxide
Label-Free Biosensor
Conducting Polymer
Gold Nanoparticles
Electrochemical Detection
Immobilization Matrix
Glucose
Nanocomposites
Issue Date: 2022
Publisher: Pergamon-Elsevier Science Ltd
Abstract: Interface design is the most crucial part of biosensor development because its rational design methodologies are directly related to the quality of sensing performance, such as sensitivity, reproducibility, stability, and linearity. In this study, a thienyl pyrrole derived electmactive monomer [N-1, N-4-bis(2,5-di(thiophene-2-yl)-1H-pyrrol-1-yl) terephthalamide] (TP) has been synthesized and electmpolymerized onto chitosan (CS) and chitosan-reduced graphene oxide (rGO) modified electrode to produce highly stable and reproducible sensor platforms for glucose detection. The synergistic interactions of chitosan and p(TP) have produced the sensor platform inherent properties such as conductivity in three dimensions, ability to covalently bind the enzyme, interface compatibility of components, hydrophilicity. CS/p(TP)/GOx bioelectrodes offer higher sensitivity (0.322 mu A mu M-1 cm(-2)), detection limit (0.097 mu M) and good selectivity compared to CS-rGO/p(TP)/GOx (0.531 mu A mu M-1 cm(-2) and 0.159 mu M) bioelectrodes. Also, CS/p(TP)/GOx bioelectrodes show excellent longer-term storage stability, retaining 98.6% sensitivity after nine weeks, whereas the CS-rGO/p(TP)/GOx bioelectrode lost initial activity in two weeks when stored at 4 degrees C. Aside from the excellent stability and sensitivity, multiple sensor electrodes prepared under the same conditions gave the same glucose response without needing to be recalibrated.
URI: https://doi.org/10.1016/j.matchemphys.2022.126397
https://hdl.handle.net/20.500.13087/3176
ISSN: 0278-6915
1873-6351
Appears in Collections:Diğer Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu

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