Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.13087/2686
Title: Advances in microfabrication technologies in tissue engineering and regenerative medicine
Authors: Nadine, Sara
Chung, Ada
Diltemiz, Sibel Emir
Yasuda, Brooke
Lee, Charles
Hosseini, Vahid
Ahadian, Samad
Keywords: 3D bioprinting
4D bioprinting
biomaterials
electrospinning
hierarchical assembly
microfabrication
microfluidics
microneedles
regenerative medicine
soft lithography
tissue engineering
Transdermal Drug-Delivery
Mesenchymal Stem-Cells
On-A-Chip
Of-The-Art
In-Vitro
Nanofibrous Scaffolds
Culture-System
Bone
Microneedles
Hydrogels
Issue Date: 2022
Publisher: Wiley
Abstract: Background Tissue engineering provides various strategies to fabricate an appropriate microenvironment to support the repair and regeneration of lost or damaged tissues. In this matter, several technologies have been implemented to construct close-to-native three-dimensional structures at numerous physiological scales, which are essential to confer the functional characteristics of living tissues. Methods In this article, we review a variety of microfabrication technologies that are currently utilized for several tissue engineering applications, such as soft lithography, microneedles, templated and self-assembly of microstructures, microfluidics, fiber spinning, and bioprinting. Results These technologies have considerably helped us to precisely manipulate cells or cellular constructs for the fabrication of biomimetic tissues and organs. Although currently available tissues still lack some crucial functionalities, including vascular networks, innervation, and lymphatic system, microfabrication strategies are being proposed to overcome these issues. Moreover, the microfabrication techniques that have progressed to the preclinical stage are also discussed. Conclusions This article aims to highlight the advantages and drawbacks of each technique and areas of further research for a more comprehensive and evolving understanding of microfabrication techniques in terms of tissue engineering and regenerative medicine applications.
URI: https://doi.org/10.1111/aor.14232
https://hdl.handle.net/20.500.13087/2686
ISSN: 0160-564X
1525-1594
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu

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