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Title: Investigation of in vitro biological activities of hollow mesoporous carbon nanoparticles bearing D-NMAPPD on human lung adenocarcinoma cells
Authors: Uğur, Naz
Harputlu, Ersan
Sezer, Canan Vejselova
Demirdöğen, Ruken Esra
İnce, Mine
Ünlü, Cumhur Gökhan
Ocakoğlu, Kasım
Keywords: Hollow mesoporous carbon nanoparticles
Lung cancer
Issue Date: 2022
Publisher: Elsevier
Abstract: The uniformly dispersed hollow mesoporous carbon nanoparticles (HMCNPs) were successfully synthesized by hard-template methods, and D-NMAPPD (B13) was successfully loaded onto the nanoparticle surface for the first time. Structural properties of bare and B13 loaded HMCNPs (HMCNs-B-13) were investigated by Fourier Transform Infrared Spectroscopy (FT-IR), Field Emission-Scanning Electron Microscopy (FE-SEM), Thermal Gravimetric Analysis (TG). The amount of drug released was determined via in vitro drug release studies at 37 degrees C in SBF through UV-Vis spectrometric and thermal analyses. TG data revealed that the proportion of loaded B-13 was 33.60%. Their ability to induce apoptosis in cultures of A549 human lung adenocarcinoma cells was investigated, and the inhibitory effect of HMCNPs-B-13 on lung cancer cell proliferation was determined in vitro. The IC50 values determined after application periods of 24 and 48 h were found to be 16.13 mu g/mL and 12.96 mu g/mL, respectively. The role of HMCNPs-B-13 on the morphology and ultrastructure of A549 cells was also investigated by confocal microscopy and Transmission electron microscopy (TEM) studies.
ISSN: 1773-2247
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu

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