Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.13087/261
Title: Synthesis, structural characterization and in vitro anticancer activity of two new nickel complexes bearing imine bonds
Authors: Ay, Burak
Gönül, İlyas
Demir, Burcu Saygıdeğer
Saygıdeğer, Yasemin
Kani, İbrahim
Keywords: Nickel complexes
Schiff base
Primary lung cancer cell
Apoptosis
Cell viability
Antitumor
Issue Date: 2020
Publisher: Elsevier
Abstract: Herein, we describe the synthesis and characterization of two novel nickel complexes, [Ni(L-1)(2)] (1) and [Ni(L-2)(2) (CH3COO)]center dot 9H(2)O(CH3COOH) (2), containing (E)-2-(((2-(diethylamino)ethyl)imino)methyl)-6-ethoxyphenol (HL1) and (E)-2-(((2-(dimethylamino)ethyl)imino)methyl)-6-methoxyphenol (HL2) ligands. Complexes have been synthesized under conventional methods and characterized by elemental analysis, FT-IR, ICP-OES, TGA, and single crystal X-ray diffraction analysis. The geometry of the 2 is also supported by magnetic susceptibility and Q-TOF LC/MS analysis. The nickel ions are in square planar and distorted octahedral coordination environments, respectively. Complex 1 and 2 crystallizes in the monoclinic C1 c1 and C1 2/c1 space group. The antitumor activities of complexes 1-2 have been investigated. Both of the complexes showed dose dependent cytotoxicity and killed the newly established lung cancer cells via apoptotic pathway. The novel nickel complexes were determined as potential antitumor agents.
URI: https://doi.org/10.1016/j.inoche.2020.107824
https://hdl.handle.net/20.500.13087/261
ISSN: 1387-7003
1879-0259
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu

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