Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.13087/2160
Title: New cytotoxic chalcone derivatives from Astragalus ponticus Pall.
Authors: Koldaş, Serkan
Demirtaş, İbrahim
Mutlu, Doğukan
Atalar, Mehmet Nuri
Ünver, Hakan
Arslan, Şevki
Keywords: Antiproliferative activity
Astragalus ponticus Pall
characterization
HeLa
isolation
natural products
Natural-Products
Antioxidant
Plants
Parts
Issue Date: 2021
Publisher: Taylor & Francis Ltd
Abstract: Astragalus ponticus Pall. species was investigated for its antiproliferative effects on HeLa cells. Two new chalcones (B5 and B8) along with eight known compounds (B1, B2, B3, B6, B7, B10, B14 and B15) were isolated by following bioactivity guided isolation methods. In addition, from non-active fraction, three cycloartane glycosides (B11, B12 and B13) were isolated. Molecular structures of these isolated compounds were revealed by using spectroscopic methods like MS, 1D and 2D NMR and a single crystal X-ray diffraction analysis. New compounds B5 and B8 showed the highest antiproliferative activities against HeLa cells (IC50 values of 36.6 and 20.6 mu M, respectively) while the rest showed high and low activities. Non-endemic species attract relatively low attention from the scientific community but this study demonstrates that valuable new compounds, which might be used as ingredients in medicinal preparations, can be obtained from these materials.
URI: http://doi.org/10.1080/14786419.2021.2012771
https://hdl.handle.net/20.500.13087/2160
ISSN: 1478-6419
1478-6427
Appears in Collections:Biyoloji Bölümü Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu

Show full item record

CORE Recommender

Page view(s)

172
checked on Oct 3, 2022

Google ScholarTM

Check

Altmetric


Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.