Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.13087/1546
Title: Can the Antivirals Remdesivir and Favipiravir Work Better Jointly? In Silico Insights
Authors: Parlak, Cemal
Alver, Özgür
Ouma, Cecil N. M.
Rhyman, Lydia
Ramasami, Ponnadurai
Keywords: Remdesivir
Favipiravir
Drug-drug interaction
DFT
QTAIM
Issue Date: 2021
Publisher: Georg Thieme Verlag Kg
Abstract: The proverb Old is gold is applicable in drug discovery and the proverb All that Glitters is not Gold is also appropriate. In the COVID-19 era, there has been a race for drugs to be effective against SARS-CoV-2. There are reports about the uses of Remdesivir and Favipiravir as existing antivirals against virus but none have been conclusive so far. In the attempts for innovations, the combination of drugs is also undertrials. Therefore, we used the densityfunctional theory method and quantum theory of atoms in moleculesto investigate drug-drug interactions involving Remdesivir and Favipiravir. The computed parameters were related to the antiviral actions of both drugs together. The results indicate enhanced antiviral activity and it will be worthy to consider additional investigations with the combination of these two drugs.
URI: https://doi.org/10.1055/a-1585-1323
https://hdl.handle.net/20.500.13087/1546
ISSN: 2194-9379
2194-9387
Appears in Collections:Kimya Mühendisliği Bölümü Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
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