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Title: Presenting and Treating Bone Infections Using Silver Ion Containing Nano-hydroxyapatite
Authors: Köse, Nusret
Köse, Aydan
Toktaş, Ayşe Gül
Doğan, Atakan
Keywords: Antibacterial
Bacterial infection
Surgical site infections (SSI)
Issue Date: 2021
Publisher: Springer Science and Business Media B.V.
Abstract: Although the cleaner surgical environment, antibiotic use, and surgical asepsis-antisepsis have reduced the incidence of infections during surgery, the risk of implant-related infections is still high. Surgical site infections, a common complication after all surgical procedures, are usually caused by the exogenous and endogenous microorganisms that enter the wound during the surgical procedure. It is a potential complication associated with any type of procedure and is among the most preventable health care-associated infection. Surgical site infections are usually localized to the incision site, but may extend into deeper structures, including musculoskeletal tissues. In orthopedic surgery the ability of the implants (joint prosthesis, intramedullary nail, external fixator, etc.) to be used for many years depends mainly on the integration of the implant with the bone and no infection in the surrounding areas. The ideal antimicrobial agent for infections should be able to reach high local concentrations without causing systemic toxicity and should not interfere with bone regeneration and implant integration with biological tissues. Despite the use of very high doses of antibiotics for implant-related infections, a relatively lower drug concentration was achieved at the target site and the success rate was not high. Since implant-related infections occur mainly in the tissues directly surrounding the implant surface, it is wiser to transport antimicrobials locally to prevent and treat these infections. Methods that prevent microbes from adhering to the surface of the implant are preferred for the prevention of infections. Given the high risk of antibiotic resistance associated with antibiotic-loaded coatings and other problems, nonantibiotic substances are a much more attractive alternative. Among the various substances, silver ion is a substance that, come forward because it prevents bacterial attachment, its broad antibacterial spectrum (both Gram negative and positive bacteria) has a long-term antibacterial effect and is less prone to resistance development. © 2021, The Author(s), under exclusive license to Springer Nature Switzerland AG.
ISSN: 2523-8027
Appears in Collections:Kimya Bölümü Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu

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