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Title: Unusual products of reaction between aminoisoxazoles and aromatic aldehydes
Authors: Koodziej, B.
Duran, Burak
Morawiak, M.
Schilf, W.
Keywords: 3-methyl-5-aminoisoxazole (5AMI)
5-methyl-3-aminoisoxazole (3AMI)
Intramolecular hydrogen bond
Schiff bases
Spectroscopic methods (1H, 13C, and 15N NMR, ATR-FTIR, UV-Vis)
Issue Date: 2022
Publisher: Elsevier B.V.
Abstract: The reaction between primary amine and aldehyde usually leads to a Schiff base. In this work, we present the results of research (NMR, ATR-FTIR, UV–Vis, and X-ray) of products obtained in the reaction of 5-methyl-3-aminoisoxazole (3AMI) or 3-methyl-5-aminoisoxazole (5AMI) with 17 different aldehydes. Based on the results, we prove that this simple and well-known reaction does not always leads to the obtaining of typical products. In addition, we present a discussion on tautomeric forms preferred by the investigated o?hydroxy imine compounds in solution and in the solid state. Knowledge of the tautomeric form which given Schiff base exists in the solution and in the solid state is very important in the development of medicine and pharmacy as well as coordination chemistry. © 2021 Elsevier B.V.
ISSN: 0022-2860
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu

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